Examination of the hallucinogen 2,5-dimethoxy-4-methylamphetamine
Journal of Pharmacy and Pharmacology January 1, 1969 DOI: 10.1111/j.2042-7158.1969.tb08122.x
Summary
AI-generated from the abstractA new hallucinogenic drug circulating under the name "STP" was identified as 2,5-dimethoxy-4-methylamphetamine (DOM). The drug was extracted from a tablet and characterized using high-resolution mass spectrometry, NMR, ultraviolet and infrared spectroscopy, and chromatography. The compound exhibited two distinct solid forms (polymorphs) that were studied by X-ray diffraction and differential scanning calorimetry. Animal behavioral tests showed its psychotomimetic activity is comparable to mescaline but up to 50 times more potent.
Study at a glance
| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Key finding | The hallucinogenic drug STP is 2,5-dimethoxy-4-methylamphetamine (DOM), which is up to 50 times more potent than mescaline in animal behavioral tests. |
Abstract
Abstract Physical characteristics are reported for a tablet form of a new hallucinogenic drug previously circulating in the USA under the name “STP”. High resolution mass, nmr, ultraviolet and infrared spectrometric evidence, which identify the extracted base as 2,5-dimethoxy-4-methylamphetamine, and its chromatographic behaviour, are compared with the experimental compound “DOM”. Polymorphic modifications exhibiting distinct solid phase infrared spectra have been studied by X-ray diffraction and by differential calorimetry. Animal behavioural tests indicate that the psychotomimetic activity of the base is comparable with mescaline but up to 50 times more potent.