Breaking through anhedonia: How ketamine reignites the drive for rewards.
Neuron May 7, 2025 DOI: 10.1016/j.neuron.2025.03.025 via PubMed
Summary
AI-generated from the abstractKetamine reverses stress-induced changes in excitatory synapses in nucleus accumbens D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs), and these changes are necessary for treating anhedonia-like behavior.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Nucleus accumbens D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs) in a stress model |
| Intervention | Ketamine |
| Keywords | Neuroscience Mental health Psychopharmacology Addiction treatment Brain chemistry |
| Key finding | Ketamine reverses stress-induced changes in excitatory synapses in nucleus accumbens D1-MSNs, and these changes are necessary for the treatment of anhedonia-like behavior. |
Abstract
In this issue of Neuron, Pignatelli et al.1 find that ketamine reverses stress-induced changes in excitatory synapses in nucleus accumbens D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs) and that these changes are necessary for the treatment of anhedonia-like behavior.