Breaking through anhedonia: How ketamine reignites the drive for rewards. Neuron May 7, 2025 Colleen A McClung Ketamine reverses stress-induced changes in excitatory synapses in nucleus accumbens D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs), and these changes are necessary for treating anhedonia-like behavior. DOI: 10.1016/j.neuron.2025.03.025 Full text Neuroscience Mental health Psychopharmacology Addiction treatment +1