Psilocybin‐assisted therapy leads to personality shifts in patients with alcohol use disorder
The Brown University Psychopharmacology Update March 27, 2025 DOI: 10.1002/pu.31300 via OpenAlex
Summary
AI-generated from the abstractAdults with alcohol use disorder who received two sessions of psilocybin-assisted therapy showed personality changes toward normalizing abnormal traits, according to a secondary analysis of a randomized trial. A decrease in impulsiveness was linked to reduced drinking after treatment, with the strongest effect among psilocybin-treated individuals who had engaged in moderate- or high-risk drinking before treatment.
Study at a glance
| Characteristics | Secondary analysis of a randomized trial Peer reviewed |
|---|---|
| Population | Adults with alcohol use disorder |
| Dose | two sessions |
| Topics | Addiction Psilocybin |
| Keywords | Medicine Psychotherapist Psychiatry |
| Key finding | Psilocybin-assisted therapy was associated with personality shifts toward normalization of abnormal trait expression, and decreased impulsiveness was linked to reduced drinking post-treatment, especially among those with moderate- or high-risk drinking before treatment. |
Abstract
Adults with alcohol use disorder who received two sessions of psilocybin‐assisted therapy demonstrated personality shifts toward normalization of abnormal trait expression, a secondary analysis of a randomized trial has found. A decrease in impulsiveness was found to be associated with reduced drinking post‐treatment, with the strongest effect for psilocybin‐treated individuals who had engaged in moderate‐ or high‐risk drinking before treatment.