Changes in default-mode network activity and functional connectivity as an indicator of psychedelic-assisted psychotherapy effectiveness
Anastasia Ruban, Aleksandra Kołodziej
Neuropsychiatria i Neuropsychologia January 1, 2018 DOI: 10.5114/nan.2018.81249 via OpenAlex
Summary
AI-generated from the abstractPsychedelic-assisted psychotherapy may work by reducing activity and functional connectivity within the default-mode network (DMN), a brain system linked to self-referential thought and rumination. The review suggests that psychedelics like psilocybin and LSD temporarily disrupt DMN integrity, allowing for a more flexible, less rigid pattern of brain activity that could help patients break out of maladaptive thought patterns. This neural change is proposed as a key indicator of therapeutic effectiveness for conditions such as depression, anxiety, and addiction. The authors call for further research to confirm the causal relationship between DMN modulation and clinical outcomes.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Default mode network |
| Keywords | Neuropsychiatry Neuropsychology Functional connectivity |
| Citations | 20 |
| Key finding | Psychedelic-assisted psychotherapy may be effective by decreasing default-mode network activity and functional connectivity, thereby disrupting rigid self-referential thinking. |
Abstract
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Ruban A, Kołodziej A. Changes in default-mode network activity and functional connectivity as an indicator of psychedelic-assisted psychotherapy effectiveness. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2018;13(3):91-97. doi:10.5114/nan.2018.81249. APA Ruban, A., & Kołodziej, A. (2018). Changes in default-mode network activity and functional connectivity as an indicator of psychedelic-assisted psychotherapy effectiveness. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, 13(3), 91-97. https://doi.org/10.5114/nan.2018.81249 Chicago Ruban, Anastasia, and Aleksandra A. Kołodziej. 2018. "Changes in default-mode network activity and functional connectivity as an indicator of psychedelic-assisted psychotherapy effectiveness". Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology 13 (3): 91-97. doi:10.5114/nan.2018.81249. Harvard Ruban, A., and Kołodziej, A. (2018). Changes in default-mode network activity and functional connectivity as an indicator of psychedelic-assisted psychotherapy effectiveness. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, 13(3), pp.91-97. https://doi.org/10.5114/nan.2018.81249 MLA Ruban, Anastasia et al. "Changes in default-mode network activity and functional connectivity as an indicator of psychedelic-assisted psychotherapy effectiveness." Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, vol. 13, no. 3, 2018, pp. 91-97. doi:10.5114/nan.2018.81249. Vancouver Ruban A, Kołodziej A. Changes in default-mode network activity and functional connectivity as an indicator of psychedelic-assisted psychotherapy effectiveness. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2018;13(3):91-97. doi:10.5114/nan.2018.81249.