Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics.

This paper examines chemical compounds that resemble the D-ring portion of LSD, analyzing how their structures relate to potential therapeutic effects. The authors review structure-activity relationships to identify which molecular features might produce beneficial outcomes without the hallucinogenic effects of LSD. They consider these analogs as possible treatments for conditions such as depression, anxiety, and cluster headaches. The work suggests that certain D-ring modifications could retain therapeutic potential while reducing unwanted side effects, though no clinical data are presented. The analysis is based on existing research and chemical principles, aiming to guide future drug development.

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Abstract

Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics.