Lysergic Acid Diethylamide (LSD): No Teratogenicity in Rats
Science February 16, 1968 DOI: 10.1126/science.159.3816.731 via OpenAlex
Summary
AI-generated from the abstractLysergic acid diethylamide (LSD) given to pregnant rats at doses from 1.5 to 300 micrograms during organogenesis and on the 4th or 5th day of pregnancy did not increase the frequency of congenital defects in the 887 offspring compared to controls. The experiments failed to prove that LSD is teratogenic in rats.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 89 |
| Population | Pregnant rats |
| Intervention | Lysergic acid diethylamide (LSD) |
| Dose | 1.5 to 300 micrograms |
| Topics | LSD |
| Keywords | Pregnancy Teratology Organogenesis Physiology |
| Citations | 55 |
| Key finding | LSD did not produce a greater frequency of congenital defects in rat offspring than in controls. |
Abstract
Lysergic acid diethylamide (LSD) in doses of 1.5 to 300 micrograms was given to 55 pregnant rats during periods of organogenesis and on the 4th or 5th day of pregnancy to 34 rats. Examination of the resultant 887 young for congenital defects showed no greater frequency than in controls. These experiments failed to prove that LSD is teratogenic in rats.