LSD: No Teratogenic Action in Rats, Mice, and Hamsters
J. Serratrice, R Dupuis, Marie Christine Aubry
Science August 7, 1970 DOI: 10.1126/science.169.3945.588 via OpenAlex
Summary
AI-generated from the abstractLysergic acid diethylamide tartrate, given as a single daily dose of 5 to 500 micrograms per kilogram of body weight to pregnant rats, mice, and hamsters either at the start of gestation or during organogenesis, did not cause abortion, birth defects, or growth suppression. Examination of 1003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses showed no evidence of such effects.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 187 |
| Population | Pregnant rats, mice, and hamsters |
| Intervention | Lysergic acid diethylamide tartrate |
| Dose | 5 to 500 micrograms per kilogram of body weight per day |
| Topics | LSD |
| Keywords | Hamster Abortifacient Gestation Fetus |
| Citations | 23 |
| Key finding | Lysergic acid diethylamide tartrate showed no abortifacient, teratogenic, or growth-depressing effects in the fetuses of rats, mice, and hamsters. |
Abstract
Lysergic acid diethylamide tartrate was given to 98 pregnant rats, 67 mice, and 22 hamsters as a single dose of 5 to 500 micrograms per kilogram of body weight per day either at the beginning of gestation or during the period of organogenesis. Examination of the 1003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses obtained failed to prove any abortifacient, teratogenic, or growth-depressing effects.