Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster
Science October 13, 1967 DOI: 10.1126/science.158.3798.265 via OpenAlex
Summary
AI-generated from the abstractA single injection of mescaline, LSD, or 2-bromo-LSD given to pregnant hamsters on the 8th day of pregnancy caused malformations in the brain, spinal cord, liver, and other organs, as well as body edema and localized hemorrhages in the fetuses. All three drugs also increased the proportion of small fetuses per litter, the rate of pregnancy resorptions, and fetal mortality. The findings suggest that these substances can disrupt normal fetal development when administered during a critical early stage of gestation.
Study at a glance
| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Fetal hamsters |
| Interventions | mescaline lysergic acid diethylamide 2-bromo-D lysergic acid diethylamide |
| Topics | LSD Mescaline |
| Keywords | Hamster Fetus Pregnancy |
| Citations | 87 |
| Key finding | A single dose of mescaline, LSD, or 2-bromo-LSD on the 8th day of pregnancy produced malformations in multiple organs and increased fetal mortality and resorptions in hamsters. |
Abstract
Malformations of the brain, spinal cord, liver, and other viscera; body edema; and localized hemorrhages were found in fetal hamsters from mothers injected subcutaneously with a single dose of mescaline, lysergic acid diethylamide, or 2-bromo-D lysergic acid diethylamide on the 8th day of pregnancy. In addition, all three drugs produced an increase in the percentages of small fetuses per litter, of resorptions, and of fetal mortality.