Investigation into the temporal stability of aqueous standard solutions of psilocin and psilocybin using high performance liquid chromatography
Nicole Anastos, Neil W. Barnett, Frederick M. Pfeffer, Simon W. Lewis
Science & Justice April 1, 2006 DOI: 10.1016/s1355-0306(06)71579-9 via OpenAlex
Summary
AI-generated from the abstractAqueous solutions of psilocin and psilocybin reference standards remain stable for up to seven days when protected from light, as measured by high-performance liquid chromatography. Excluding light significantly prolongs their useful life. The study used a methanol and ammonium formate mobile phase with detection at 269 nm over a fourteen-day period.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Duration | Fourteen days |
| Topics | Psilocybin |
| Keywords | Chromatography Chemistry Ingredient Hallucinogen |
| Citations | 27 |
| Key finding | Exclusion of light significantly prolonged the stability of aqueous psilocin and psilocybin solutions, with both remaining stable for seven days. |
Abstract
This paper reports an investigation into the temporal stability of aqueous solutions of psilocin and psilocybin reference drug standards over a period of fourteen days. This study was performed using high performance liquid chromatography utilising a (95:5% v/v) methanol: 10 mM ammonium formate, pH 3.5 mobile phase and absorption detection at 269 nm. It was found that the exclusion of light significantly prolonged the useful life of standards, with aqueous solutions of both psilocin and psilocybin being stable over a period of seven days.