Effects of LSD-25 on Food Intake in the Rat.
Charles Hamilton, Chester R. Wilpizeski
Experimental Biology and Medicine November 1, 1961 DOI: 10.3181/00379727-108-26925 via OpenAlex
Summary
AI-generated from the abstractInjection of LSD-25 suppresses food intake in rats, and this effect depends on the dose given. Over ten daily injections, food intake remained suppressed each day, indicating that complete tolerance did not develop. These results suggest caution when interpreting behavioral effects of LSD-25 in experiments where behavior relies on food reinforcement.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Duration | 10 daily injections |
| Keywords | Food intake Reinforcement Physiology Food science Endocrinology |
| Citations | 13 |
| Key finding | LSD-25 suppresses food intake in rats in a dose-dependent manner, and repeated daily injections do not lead to complete tolerance. |
Abstract
Suppression of food intake in the rat was shown to follow injection of LSD-25 and this effect was determined to be dose dependent. When the effects of 10 daily injections of the drug were investigated, a suppression of food intake on each day indicated a lack of development of complete tolerance. These data show that caution is needed in interpretation of the behavioral effects of LSD-25 where such behavior is dependent upon food reinforcement.