LSD-Induced Decrease in Serum Prolactin in Rats
Experimental Biology and Medicine September 1, 1971 DOI: 10.3181/00379727-137-35764 via OpenAlex
Summary
AI-generated from the abstractA single injection of LSD (25, 50, or 100 μg per 100 g of body weight) given to female rats on the morning of proestrus significantly lowered serum prolactin levels and blocked the normal afternoon rise seen in control rats. The highest dose produced a greater decrease than the lowest dose. This effect is similar to that of other ergot drugs.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Female rats on the morning of proestrus |
| Intervention | LSD |
| Dose | 25, 50, or 100 μg per 100 g of body weight |
| Topics | LSD |
| Keywords | Prolactin Endocrinology Internal medicine Morning |
| Citations | 7 |
| Key finding | LSD injection on the morning of proestrus significantly decreased serum prolactin levels and prevented the normal afternoon rise in female rats. |
Abstract
SummaryA single ip injection of 25, 50, or 100 μg of LSD (lysergic acid diethylamide)/100 g of body weight into female rats on the morning of proestrus significantly decreased serum prolactin levels, and prevented the normal rise observed in control rats on the afternoon of proestrus. The 100-μg dose of LSD produced a significantly greater decrease in serum prolactin than the 25-μg dose. This action of LSD is shared by other ergot drugs.