Persistence of lysergic acid diethylamide in the plasma of human subjects
Clinical Pharmacology & Therapeutics September 1, 1964 DOI: 10.1002/cpt196455611 via OpenAlex
Summary
AI-generated from the abstractAfter intravenous administration of two micrograms per kilogram of LSD-25 to five healthy adults, the drug was detected in plasma at relatively high concentrations during the period of peak effect. The half-life of LSD-25 in human plasma was calculated to be 175 minutes.
Study at a glance
| Characteristics | Pharmacokinetic study Peer reviewed |
|---|---|
| Sample size | 5 |
| Population | Normal human subjects |
| Dose | two micrograms per kilogram |
| Duration | 8 hours |
| Topics | LSD |
| Keywords | Human plasma Persistence discontinuity Plasma levels Half-life |
| Citations | 118 |
| Key finding | The half-life of LSD-25 in human plasma is 175 minutes. |
Abstract
Two micrograms per kilogram of LSD‐25 was administered intravenously to five normal human subjects. The concentration of drug in plasma was determined serially over the subsequent 8 hours. LSD‐25 was found to be present in human plasma in relatively large quantities during the period of peak effect. The half‐life of LSD‐25 in human plasma was calculated to be 175 minutes.