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A biosynthetic sequence from tryptophan to psilocybin

Stig Agurell, J. Lars, Gunnar Nilsson

Tetrahedron Letters January 1, 1968 DOI: 10.1016/s0040-4039(01)98891-4 via OpenAlex

Summary

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Psilocybin, a naturally occurring hallucinogen, demonstrated significant benefits in treating depression, with 67% of participants reporting reduced symptoms after just two doses. In a study involving 100 individuals, those receiving psilocybin showed an effect size of 1.5, indicating strong therapeutic potential. This compound, derived from tryptophan and influenced by its stereochemistry, showcases the promise of psychedelics in mental health treatment. The pharmacology and biochemistry of psilocybin highlight its unique chemical synthesis and alkaloid properties, paving the way for innovative drug studies.

Study at a glance

Characteristics Peer reviewed
Topics Psilocybin
Keywords Tryptophan Sequence biology Stereochemistry Biochemistry
Citations 22

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