LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice
Juhana E. Idänpään-heikkilä, Joseph C. Schoolar
Science June 13, 1969 DOI: 10.1126/science.164.3885.1295 via OpenAlex
Summary
AI-generated from the abstractIntravenously administered 14C-lysergic acid diethylamide rapidly moved from blood into tissues within minutes. The highest uptake occurred in the brain, adrenals, hypophysis, kidneys, liver, and lungs, far exceeding blood concentrations. Biliary excretion began immediately and was the primary elimination route. During early pregnancy, 2.5% of the radioactive dose crossed the placental barrier into the fetus within five minutes; in late pregnancy, this dropped to 0.5%. More than 70% of the fetal radioactivity remained as unchanged 14C-lysergic acid diethylamide.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Pregnant subjects (early and late stage pregnancy) |
| Intervention | 14 C-lysergic acid diethylamide administered intravenously |
| Keywords | Fetus Placenta Distribution mathematics Endocrinology Internal medicine |
| Citations | 32 |
| Key finding | Lysergic acid diethylamide rapidly distributes to multiple organs and crosses the placental barrier, with higher transfer in early versus late pregnancy. |
Abstract
14 C-lysergic acid diethylamide administered intravenously passed in a few minutes from the blood into the tissues. In addition to the brain, the adrenals, hypophysis, kidneys, liver, and lungs showed the highest uptake, much higher than the blood concentration. Excretion into the bile started immediately; this was the most important elimination route. In the early stage of pregnancy, 2.5 percent (and in the late stage, 0.5 percent) of the radioactive dose passed the placental barrier into the fetus in 5 minutes. Over 70 percent of this fetal radioactivity was unchanged 14 C-lysergic acid diethylamide.