Analysis of Phenethylamines and Tryptamines in Designer Drugs Using Gas Chromatographymass Spectrometry
Misako Takahashi, Machiko Nagashima, Jin Suzuki, Takako Seto, Ichirou Yasuda, Takemi Yoshida
JOURNAL OF HEALTH SCIENCE January 1, 2008 DOI: 10.1248/jhs.54.89 via OpenAlex
Summary
AI-generated from the abstractA method using gas chromatography-mass spectrometry (GC-MS) was developed to identify ten psychedelic phenethylamines and tryptamines, including 2C-B, 2C-I, 5-MeO-DMT, and 5-MeO-DIPT. Five reference standards were newly synthesized, and five were purified; all were confirmed by GC-MS and NMR spectroscopy. Between April 2005 and March 2007, eight of the ten compounds were detected in 100 out of 178 examined products.
Study at a glance
| Characteristics | Method development and survey Peer reviewed |
|---|---|
| Sample size | 178 |
| Population | Products containing psychedelic phenethylamines and tryptamines |
| Duration | April 2005 to March 2007 |
| Keywords | Tryptamines Phenethylamines Chemistry Gas chromatography–mass spectrometry Designer drug |
| Citations | 24 |
| Key finding | Eight of the ten target psychedelic compounds were found in 100 of 178 products analyzed between 2005 and 2007. |
Abstract
We developed a method for determining the following ten psychedelic phenethylamines and tryptamines by gas chromatography-mass spectrometry (GC-MS). The phenethylamines examined were 3,4,5-trimethoxyamphetamine (TMA), 2,4,5-trimethoxyamphetamine (TMA-2), 4-bromo-2,5-dimethoxyphenethylamine (2C-B), 4-iodo-2,5-dimethoxyphenethylamine (2C-I), 2,5-dimethoxy-4-ethylthiophenethylamine (2CT-2), and 2,5-dimethoxy-4-propylthiophenethylamine (2CT-7). The tryptamines examined were 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), α-methyltryptamine (AMT), N-isopropyl-5-methoxy-N-methyltryptamine (5-MeO-MIPT), and N,N-diisopropyl-5-methoxytryptamine (5-MeO-DIPT). As the reference standards, five compounds were newly synthesized, and five were purified from the products. These were all structurally ascertained by GC-MS and nuclear magnetic resonance (NMR) spectroscopy. Between April 2005 and March 2007, 8 compounds analyzed in this study were found in 100 out of the 178 products which were examined.