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Psilocybin, a fast-acting antidepressant used with psychotherapy, does not appear to improve or impair memory consolidation of material learned outside of acute intoxication. In a placebo-controlled, double-blind, cross-over study with 20 healthy volunteers, psilocybin had no effect on declarative memory consolidation immediately after a session or on overnight consolidation the following night, as measured by the Groton Maze Learning Task, Rey Auditory Verbal Learning Test, and Pair Associative Learning Test. These findings contribute to the safety profile of psilocybin in therapeutic settings.

Study at a glance

Abstract

Psilocybin is investigated as a fast-acting antidepressant used in conjunction with psychotherapy. Intact cognitive functions, including memory, are one of the basic conditions of effective psychedelic-assisted therapy. While cognitive and memory processing is attenuated on various domains during psilocybin intoxication, the effect of psilocybin on the consolidation of memories learned outside of acute intoxication is not known. Thus the main aim of the current study was to test the effects of psilocybin on (A) memory consolidation of previously learned material just after the psilocybin session and (B) on overnight memory consolidation the night just after the psilocybin session. 20 healthy volunteers (10 M/10F) were enrolled in a placebo-controlled, double-blind, cross-over design. Effects on declarative memory consolidation in condition (A) The Groton Maze Learning Task and Rey Auditory Verbal Learning Test were used, and for (B) the Pair Associative Learning Test was used. We did not find psilocybin to improve memory consolidation. At the same time, we did not find psilocybin to negatively affect memory consolidation in any of the tests used. This evidence adds to the safety profile for the use of psilocybin.