Stimulation of human prolactin secretion by mescaline
Psychopharmacology September 1, 1979 DOI: 10.1007/bf00427525 via OpenAlex
Summary
AI-generated from the abstractOral administration of 5 mg/kg mescaline stimulated prolactin secretion more than four-fold above baseline in humans, with peak concentrations 90–120 minutes after intake and levels still markedly elevated five hours later. Mescaline also triggered growth hormone secretion. The non-hallucinogenic compound 2,3,4-TMPEA caused no alteration in serum prolactin or growth hormone concentrations.
Study at a glance
| Characteristics | Controlled study Peer reviewed |
|---|---|
| Population | Humans |
| Interventions | Mescaline 2 3 4-trimethoxy-beta-phenylethylamine |
| Dose | 5 mg/kg |
| Topics | Mescaline |
| Keywords | Stimulation Prolactin Secretion Endocrinology |
| Citations | 8 |
| Key finding | Mescaline stimulated prolactin secretion more than four-fold above baseline and triggered growth hormone secretion, while the non-hallucinogenic 2,3,4-TMPEA had no effect. |
Abstract
Prolactin (PRL) and Growth Hormone (GH) secretions were studied in human serum after the oral administration of 5 mg/kg mescaline (3,4,5-trimethoxy-beta-phenylethylamine) or 2,3,4-trimethoxy-beta-phenylethylamine (2,3,4-TMPEA) respectively. Mescaline stimulated the secretion of PRL more than four-fold above base-line levels. Peak concentrations were found 90--120 min after drug intake. Five hours later serum PRL was still markedly increased. Mescaline also triggered GH secretion. There was no alteration of serum PRL and GH concentrations after intake of the non-hallucinogenic 2,3,4-TMPEA.