Bioassay of Ataractics Against Lethal Action of Mescaline in Mice
Nicholas P. Plotnikoff, Helen Washington
Experimental Biology and Medicine July 1, 1958 DOI: 10.3181/00379727-98-24143 via OpenAlex
Summary
AI-generated from the abstractChlorpromazine, perphenazine, proclorperazine, promazine, thiopropazate, promethazine, and reserpine effectively block mescaline-induced death in CF1 mice. In contrast, sodium phenobarbital, meprobamate, benactyzine, atropine, hydroxyzine, ethoxybutamoxane, SY-21, diphenylhydantoin, trimethadione, lysergic acid diethylamide, serotonin, amphetamine, morphine, pyrilamine, diphenhydramine, iproniazid, pilocarpine, and arecoline offered no significant protection. The protective effects of the ataractics are suggested to be centrally mediated.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | CF1 mice |
| Interventions | chlorpromazine perphenazine proclorperazine promazine thiopropazate promethazine reserpine sodium phenobarbital meprobamate benactyzine atropine hydroxyzine ethoxybutamoxane SY-21 diphenylhydantoin trimethadione lysergic acid diethylamide serotonin amphetamine morphine pyrilamine diphenhydramine iproniazid pilocarpine arecoline |
| Topics | Mescaline |
| Keywords | Promethazine Pharmacology Chlorpromazine Perphenazine |
| Citations | 7 |
| Key finding | Chlorpromazine, perphenazine, proclorperazine, promazine, thiopropazate, promethazine, and reserpine are effective antagonists of mescaline-induced mortality in CF1 mice. |
Abstract
1. It has been demonstrated that chlorpromazine, perphenazine, proclorperazine, promazine, thiopropazate, promethazine and reserpine are effective antagonists of mescaline-induced mortality in CF1 mice. 2. No significant protection was found with use of sodium phenobarbital, meprobamate, benactyzine, atropine, hydroxyzine, ethoxybutamoxane, SY-21, diphenylhydantoin, trimethadione, lysergic acid diethylamide, serotonin, amphetamine, morphine, pyrilamine, diphenhydramine, iproniazid, pilocarpine, and arecoline. 3. It is suggested that the protective effects of the ataractics against mescalineinduced mortality are centrally mediated.