Rabbits produced antibodies that specifically bind mescaline after being immunized with conjugates of bovine serum albumin and mescaline or its analogue 3,4,5-trimethoxyphenylacetic acid. Immunized rats that received mescaline showed behavioral differences compared to non-immunized controls, suggesting that the antibodies altered the drug's effects.
Immunization with mescaline conjugates raised antibodies that bound mescaline and altered behavioral responses to the drug in rats.
Abstract
Antibodies with mescaline binding specificity were raised in rabbits by immunization with conjugates of bovine serum albumin with mescaline or its analogue 3,4,5-trimethoxyphenylacetic acid. Immunized rats were given mescaline and their behavior was compared to that of non-immunized controls.