Extraction of N, N-dimethyltryptamine (DMT) from Mimosa tenuiflora, syn. Mimosa hostilis (Tepescohuite) using supercritical CO 2 and study of its surface activity

Supercritical CO2 extraction of Mimosa tenuiflora (Tepescohuite) bark yields N,N-dimethyltryptamine (DMT), an indole alkaloid with potential for neuropsychiatric, antiseptic, and wound-healing applications. Extractions were conducted at 314–328 K and 8–22 MPa. The extract's surface tension in water was measured at 308.15 K, and its foaming properties were evaluated at 298.15 K. The work suggests M. tenuiflora is a sustainable source of bioactive and surface-active compounds for pharmaceutical and biotechnological use.

Study at a glance

Abstract

This study presents the extraction and characterisation of bioactive compounds from Mimosa tenuiflora (syn. Mimosa hostilis), known as Tepescohuite, using supercritical CO2. Extractions were performed at 314-328 K and 8-22 MPa for 90 min, with CO2 flow rates of 40-50 mL·min-1. The extracts were analysed by HPLC-MS, NMR, UV-Vis and FTIR spectroscopy. The major compound identified was N, N-dimethyltryptamine (DMT), an indole alkaloid with therapeutic potential in neuropsychiatric treatments, antiseptic formulations and wound healing. The interfacial behaviour of the extract was studied by surface tension measurements of aqueous solutions at 308.15 K using the drop volume method, and its foaming properties were evaluated by the Ross-Miles method at 298.15 K. The findings demonstrate the potential of M. tenuiflora as a sustainable source of bioactive and surface-active compounds for pharmaceutical and biotechnological applications.