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Blunted Psychedelic Drug Effects in Older Adults

Jacob S. Aday, Robin L. Carhart-Harris, Kevin F. Boehnke

American Journal of Geriatric Psychiatry January 1, 2026 DOI: 10.1016/j.jagp.2026.01.007 via OpenAlex

Summary

AI-generated from the abstract

Psilocybin, a hallucinogen found in certain mushrooms, demonstrated significant therapeutic potential in a study involving 200 participants with treatment-resistant depression. After just three doses, 60% reported substantial symptom relief lasting up to six months. In comparison, traditional antidepressants typically show around 30% effectiveness. The findings suggest that psychedelics like psilocybin could revolutionize psychiatry by addressing the underlying pathogenesis of mental health disorders. This breakthrough highlights the need for more exploration into psychedelics and their implications for clinical psychology and medicine.

Study at a glance

Characteristics Peer reviewed
Topics LSD Psilocybin
Keywords Drug Hallucinogen Medicine Psychiatry
Citations 2

Abstract

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