Psilocybin as a Serotonergic Therapy in Epilepsy: Narrative Review of Therapeutic Potentials and Seizure Risks
Miguel Benjamín Cervera-Sánchez, Daniel San-Juan, Roberto Díaz-peregrino, Evelin Zulema Camacho-Castillo, Sthefany Anahi Bringas-Ortiz, Christian Padilla-Cabezutd
December 29, 2025 DOI: 10.22541/au.176701186.65064859/v1 via OpenAlex
Summary
AI-generated from the abstractPsilocybin shows promise for treating neuropsychiatric disorders, but its relationship with seizures and epilepsy is paradoxical. A narrative review of literature up to November 2025 examined this connection. The review suggests that while psilocybin may have therapeutic potential, its effects on seizure activity are complex and not fully understood, requiring further investigation to clarify risks and benefits.
Study at a glance
| Characteristics | Narrative review |
|---|---|
| Topics | Psilocybin Serotonin |
| Keywords | Narrative review Medicine Psychotherapist |
| Key finding | Psilocybin presents a paradoxical relationship with seizures and epilepsy, indicating both potential therapeutic effects and risks that are not yet fully understood. |
Abstract
Background: Psilocybin has shown promise in neuropsychiatric disorders but presents a paradoxical relationship with seizures and epilepsy. Methods: A narrative review was conducted up to November 23, 2025. We conducted structured literature searches a