Three-decade research development of ibogaine use for the treatment of substance-related disorders: a bibliometric analysis
Maria Helha Fernandes-Nascimento, André Brooking Negrão, Karine Viana-Ferreira, Bruno Rasmussen Chaves, Yuan‐pang Wang
Research Square September 8, 2022 DOI: 10.21203/rs.3.rs-2031631/v1 via OpenAlex
Summary
AI-generated from the abstractA bibliometric analysis of publications on ibogaine for treating substance-related disorders from 1991 to 2020 found that research output grew steadily, with an increase of 5.1 publications per year between 1991 and 2000. The subsequent two decades showed continued but fluctuating publication volumes, with the United States being the most prominent contributor. The analysis suggests that despite variations over time, research on ibogaine persists and points toward future directions for public health interventions.
Study at a glance
| Characteristics | Bibliometric analysis Peer reviewed |
|---|---|
| Population | Publications on ibogaine for substance-related disorders |
| Keywords | Substance use Psychology Traditional medicine Psychiatry |
| Key finding | Publications on ibogaine for treating substance use disorders grew by 5.1 per year from 1991 to 2000, with continued but fluctuating output through 2020, led by the United States. |
Abstract
Abstract Objective To evaluate the publications on ibogaine use for substance-related disorders treatment over the last three decades. Method Bibliometric analysis of publications on ibogaine for the treatment of substance-related disorders from 1991 to 2020 using VOSviewer software. We performed a Scopus database search using the terms: ibogaine, 12-methoxybogamine, endabuse, tabernanthe iboga, NIH-10567, and noribogaine. Publications related to ibogaine was compared between the three decades using the Tukey test at 95% confidence level, and the behavior period evaluated considered linear and polynomial regression models. Results Regression models indicated that publications dedicated to ibogaine for treating substance use disorders grew by 5.1 publications per year between 1991–2000 (R2 = 0.993). The period from 2001 to 2020 showed a different expansion compared to the previous period, with fluctuations within a constant flow of publications and an increase in the volume of publications was observed until the middle of this decade (R2 = 0.889). The same tendency was seen in the last decade, 2011–2020 (R2 = 0.949). The US is the most prominent country. Conclusion The present study indicates that, despite differences and fluctuations among the decades analyzed, publications continue year by year and propose future directions for new interventions in the public health.