Ex Vivo Effect of Ibogaine on the Transcriptional Level of Antioxidant Defense Related Genes in Honey Bee (Apis mellifera, L.) Midgut

Elvira Vukašinović, Jelena Purać, Danijela Kojić, Tatjana Čelić, Ivan Pihler, Duško Blagojević

Brazilian Archives of Biology and Technology January 1, 2021 DOI: 10.1590/1678-4324-2021200773 via OpenAlex

Summary

AI-generated from the abstract

The effects of ibogaine on antioxidant mechanisms remain incompletely understood. Using honey bee midgut as an ex vivo model system, ibogaine treatment induced up-regulation of the Sod1 gene, indicating a pro-antioxidant action.

Study at a glance

Characteristics	Ex vivo study Peer reviewed
Population	Honey bee midgut
Intervention	Ibogaine
Keywords	Ex vivo Midgut Antioxidant Biology In vivo
Citations	2
Key finding	Ibogaine treatment induced up-regulation of the Sod1 gene in honey bee midgut, suggesting a pro-antioxidant action.

Abstract

HIGHLIGHTS The ibogain action has not been completely clarified. Honey bee midgut is suitable model system for testing the antioxidative mechanisms. The ex vivo ibogaine treatment induced an up-regulation of Sod1 gene. Ibogaine shows pro-antioxidant action.

Summary

Study at a glance

Abstract

Related reading

Comments