[Altered states of consciousness induced by N,N-dimethyltryptamine (DMT)].
P Bickel, A Dittrich, J Schoepf
Pharmakopsychiatrie, Neuro-Psychopharmakologie September 1, 1976 DOI: 10.1055/s-0028-1094495 via PubMed
Summary
AI-generated from the abstractA controlled study on 38 volunteers assessed the effects of 250 mcg/kg DMT injected intramuscularly, with 26 receiving the drug and 12 receiving a placebo. Despite the low dose compared to earlier studies, significant differences from placebo emerged across multiple syndromes of altered consciousness: visual hallucinations or illusions, impaired memory and attention, changes in body image, depersonalization, derealization, euphoria, an anxious-depressive state, and delusion. Somatic side effects included subjective respiratory troubles, dizziness, and weakness.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 38 |
| Population | Volunteers |
| Interventions | N N-Dimethyltryptamine (DMT) |
| Dose | 250 mcg/kg |
| Citations | 12 |
| Key finding | A low dose of DMT (250 mcg/kg) produced significant differences from placebo across multiple altered states of consciousness syndromes and somatic side effects. |
Abstract
In a controlled study on 38 volunteers the effects of 250 mcg/kg N,N-Dimethyltryptamine (DMT) i.m. were assessed. 26 subjects received DMT and 12 placebo. The altered states of consciousness and the somatic changes were measured by several questionnaires administered after the experiment. In spite of the low dose as compared to previous studies significant differences to placebo were found in the following syndromes of altered states of consciousness: visual hallucinations rep. illusions, impairment of memory and attention, changes of body image, depersonalization syndrome, derealization syndrome, euphoric state, anxious-depressive state and delusion. The somatic side effects were mainly subjective respiratory troubles, dizziness and weakness.