Biochemical and Histopathological Evaluations of the Kidney and Liver in Ketamine-Induced Schizophrenic Model in Wistar Rats
Okwuchukwu Adachukwu Heavenah, Ugochukwu Samuel Aguwa, Ukoha Ukoha
Preprints.org July 3, 2026 preprint DOI: 10.20944/preprints202607.0226.v1
Summary
AI-generated from the abstractIn a ketamine-induced schizophrenic model using Wistar rats, ketamine administration caused significant biochemical and histopathological changes in the kidney and liver. Biochemical analyses revealed elevated markers of kidney and liver damage, while histopathological examination showed structural alterations in both organs. These findings suggest that ketamine, used to model schizophrenia, induces toxicity in the kidney and liver, indicating potential organ damage associated with the model.
Study at a glance
| Characteristics | Experimental study |
|---|---|
| Population | Wistar rats |
| Intervention | Ketamine |
| Key finding | Ketamine administration in a schizophrenic rat model caused significant biochemical and histopathological damage to the kidney and liver. |
Abstract
Biochemical and Histopathological Evaluations of the Kidney and Liver in Ketamine-Induced Schizophrenic Model in Wistar Rats