Biochemical and Histopathological Evaluations of the Kidney and Liver in Ketamine-Induced Schizophrenic Model in Wistar Rats
Preprints.org July 3, 2026 Okwuchukwu Adachukwu Heavenah, Ugochukwu Samuel Aguwa, Ukoha Ukoha preprint
In a ketamine-induced schizophrenic model using Wistar rats, ketamine administration caused significant biochemical and histopathological changes in the kidney and liver. Biochemical analyses revealed elevated markers of kidney and liver damage, while histopathological examination showed structural alterations in both organs. These findings suggest that ketamine, used to model schizophrenia, induces toxicity in the kidney and liver, indicating potential organ damage associated with the model.