The Relationship Between Ketamine and Memory Impairment: A Systematic Review

A systematic review of 50 studies found consistent evidence for a negative association between ketamine use and memory deterioration. The relationship is complex and challenging to characterize; some studies examined gender differences but yielded inconclusive results. Ketamine's effects extend beyond cognition to depression, suicidal ideation, and other neurocognitive functions. Further research is required to clarify this association.

Study at a glance

Abstract

Various studies have reported conflicting results regarding the effect of ketamine on cognitive function, although increasing evidence supports its impact. This study aimed to investigate the potential correlation between Ketamine usage and memory deterioration, which is crucial for informing clinical practice and public health interventions. A systematic review was conducted, and six databases were scanned according to the PRISMA guidelines. As a result, 50 studies were analyzed to investigate the relationship between Ketamine and memory deterioration. It was found that most studies provided evidence for the claim that there is a negative association between Ketamine and cognitive function, specifically in the realm of memory. Some studies emphasized gender differences; however, their results were inconclusive. Studies have also found that the impact of ketamine is not limited to cognitive functions; it extends to other aspects such as depression, suicidal ideation, and neurocognitive functions. In conclusion, it is evident that there is an association between Ketamine and memory deterioration however, this relationship is challenging to develop and further studies are required.