Data from Is It Time to Advance the Chemoprevention of Environmental Carcinogenesis with Microdosing Trials?

This perspective discusses using microdosing with environmental carcinogens to speed up the testing and improvement of chemopreventive treatments. It covers the need for preventing cancer caused by environmental factors, the design of microdosing (phase 0) trials, the technologies needed for such studies, and ethical issues. It also reviews lessons learned from microdosing research so far.

Study at a glance

Abstract

AbstractThis perspective on Jubert et al. (beginning on page [1015] in this issue of the journal) discusses the use of microdosing with environmental carcinogens to accelerate the evaluation and optimization of chemopreventive interventions. The need for chemoprevention of environmental carcinogenesis is considered, as are the structure of microdosing, or phase 0, trials, technologies required to conduct microdose studies in this context, and ethical concerns. We also reflect on what microdosing studies have taught us to date.