This perspective discusses using microdosing with environmental carcinogens to speed up the testing and improvement of chemopreventive treatments. It covers the need for preventing cancer caused by environmental factors, the design of microdosing (phase 0) trials, the technologies needed for such studies, and ethical issues. It also reviews lessons learned from microdosing research so far.
This perspective discusses using microdosing with environmental carcinogens to speed up the evaluation and improvement of chemopreventive interventions. It considers the need for chemoprevention of environmental carcinogenesis, the structure of microdosing or phase 0 trials, the technologies required for such studies, and ethical concerns. It also reflects on what microdosing studies have taught so far.