Behavioral thermoregulation in rats during hyperthermia induced by lysergic acid diethylamide
Naotoshi Murakami, Yoshihiro Sakai, Shigeki Ooki
Neuroscience Letters January 1, 1980 DOI: 10.1016/0304-3940(80)90242-6 via Elsevier
Summary
AI-generated from the abstractIn rats trained to press a bar to escape radiant heat, intraperitoneal injections of LSD (8-16 micrograms) dose-dependently increased bar-pressing rates. During this increase, rectal temperature rose while tail-skin and selected ambient temperature decreased. The findings suggest LSD-induced hyperthermia results from action on effector pathways rather than an upward resetting of the thermostat.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Free moving rats |
| Dose | 8-16 micrograms |
| Citations | 9 |
| Key finding | LSD-induced hyperthermia is mediated through action on effector pathways, not by an upward setting of the thermostat. |
Abstract
In free moving rats trained to press a bar to escape from radiant heat, lysergic acid diethylamide (LSD, 8-16 micrograms) produced a significant and dose-dependent increase of the bar-pressing rate when injected intraperitoneally. During the increase in the bar-pressing rate, the rectal temperature showed an increase and both the tail-skin and the ambient temperature selected decreased concomitantly. The results indicate that LSD-induced hyperthermia is not due to an upward setting of the thermostat but mediated through the action of LSD on the effector pathways in the rats.