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Toward the Enlightened Self: How Mindfulness and Psychedelics Relate to Self-Transcendence and Connectedness

Minka Witke, Paweł Holas

October 16, 2025 preprint DOI: 10.31234/osf.io/qkvsh_v1 via OpenAlex

Summary

AI-generated from the abstract

Mindfulness practice and psychedelic experiences are both linked to self-transcendence and nondual awareness, with ego dissolution acting as a key mediator in these connections. Ecological awareness also relates to a self-transcendent orientation. The findings suggest that these practices may foster a sense of expanded self and connection to the world, though the phenomena remain complex and require diverse research methods.

Study at a glance

Characteristics Cross-sectional survey
Sample size 1,164
Population International adults, primarily from the United States, Canada, the United Kingdom, and Poland
Topics Meditation
Keywords Spirituality Religiosity Mediation Contemplation
Key finding Mindfulness practice and psychedelic experiences are positively associated with self-transcendence and nondual awareness, with ego dissolution mediating these links.

Abstract

Objective. Spirituality and religiosity have long been associated with experiences that transcend ordinary self-awareness, often described as mystical union or nondual awareness. This study examines the concept of the “enlightened self” as a transcendent ideal, focusing on the role of mindfulness practice and psychedelic experiences in fostering self-transcendence, nondual awareness, and ecological connectedness.Method. A total of 1,164 participants (668 men, 433 women, and 63 other) were recruited internationally, primarily from the United States (n = 502), Canada (n = 67), the United Kingdom (n= 59), and Poland (n = 50). They completed validated self-report measures of mindfulness traits, contemplative practice frequency and duration, lifetime psychedelic use and intensity, ego dissolution, self-transcendence, nondual awareness, and ecological awareness. Analyses included correlational, regression, and mediation models.Results. Mindfulness practice and psychedelic experiences were positively associated with self-transcendence and nondual awareness. Ego dissolution emerged as a significant mediator linking both practices with nondual awareness. Ecological awareness was also positively associated with self-transcendent orientation.Conclusions. Findings suggest that mindfulness and psychedelics may contribute to experiences of self-transcendence and ecological connectedness. These phenomena remain complex to define and study, underscoring the need for multimethod approaches to capture their depth and diversity.

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