Lysergic acid diethylamide: Role in conversion of plasma tryptophan to brain serotonin (5-hydroxytryptamine)
Robert C. Lin, S. H. Ngai, E. Costa
Science January 1, 1969 DOI: 10.1126/science.166.3902.237 via Elsevier
Summary
AI-generated from the abstractInjections of D-lysergic acid diethylamide (LSD) reduce the turnover rate of the neurotransmitter serotonin (5-hydroxytryptamine) in rat brain, measured by the conversion of radiolabeled tryptophan into radiolabeled serotonin. In contrast, a related compound, 2-bromolysergic acid diethylamide, given at five times the dose of LSD, does not alter this conversion rate. The finding is discussed in relation to LSD's effects on brain serotonergic neurons and its ability to produce psychosis-like symptoms.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rat brain |
| Interventions | D-lysergic acid diethylamide 2-bromolysergic acid diethylamide |
| Citations | 69 |
| Key finding | D-lysergic acid diethylamide decreases the turnover rate of 5-hydroxytryptamine in rat brain, while 2-bromolysergic acid diethylamide does not. |
Abstract
Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of (14)C-tryptophan into (14)C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of (14)C-tryptophan conversion into (14)C-5-hydroxytryptamine. The effect of D-lysergic acid diethylamide is discussed with regard to its action on brain serotonergic neurons and its psychotomimetic effects.