The effect of lysergic acid diethylamide, 5-hydroxytryptamine, and related compounds on the liver fluke, Fasciola hepatica
British Journal of Pharmacology and Chemotherapy December 1, 1957 DOI: 10.1111/j.1476-5381.1957.tb00156.x via Elsevier
Summary
AI-generated from the abstract5-hydroxytryptamine and lysergic acid diethylamide stimulate the rhythmical activity of the liver fluke Fasciola hepatica at very low concentrations, acting peripherally rather than through the central ganglion. Other amines, particularly indolamines, also stimulate rhythmical activity. Bromolysergic acid diethylamide, yohimbine, harmine, and dopamine depress rhythmical movement and counteract the stimulant effects of 5-hydroxytryptamine and lysergic acid diethylamide. Evidence suggests the presence of tryptamine receptors in the trematode.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Liver fluke (Fasciola hepatica) |
| Interventions | 5-hydroxytryptamine lysergic acid diethylamide bromolysergic acid diethylamide yohimbine harmine dopamine |
| Dose | very low concentrations |
| Citations | 51 |
| Key finding | 5-hydroxytryptamine and lysergic acid diethylamide stimulate rhythmical activity in Fasciola hepatica at low concentrations, while certain analogues depress this activity and antagonize the stimulants. |
Abstract
The rhythmical activity of the liver fluke, Fasciola hepatica, was stimulated by 5-hydroxytryptamine and by lysergic acid diethylamide at very low concentrations. The effect was peripheral and was not mediated through the central ganglion. Other amines also stimulated rhythmical activity, the most potent being the indolamines.Bromolysergic acid diethylamide, and other analogues such as yohimbine, harmine, and dopamine depressed rhythmical movement and antagonized the stimulant action of 5-hydroxytryptamine and lysergic acid diethylamide. Evidence which suggests the presence of tryptamine receptors in the trematode is discussed.