The effect of lysergic acid diethylamide, 5-hydroxytryptamine, and related compounds on the liver fluke, Fasciola hepatica
British Journal of Pharmacology and Chemotherapy December 1, 1957 T. E. Mansour 51 citations
5-hydroxytryptamine and lysergic acid diethylamide stimulate the rhythmical activity of the liver fluke Fasciola hepatica at very low concentrations, acting peripherally rather than through the central ganglion. Other amines, particularly indolamines, also stimulate rhythmical activity. Bromolysergic acid diethylamide, yohimbine, harmine, and dopamine depress rhythmical movement and counteract the stimulant effects of 5-hydroxytryptamine and lysergic acid diethylamide. Evidence suggests the presence of tryptamine receptors in the trematode.