Blockade of 5-Hydroxytryptamine Antidiuresis in Rats by 2-Bromlysergic Acid Diethylamide Tartrate and 1-Methyl-Lysergic Acid Butanolamide
Journal of Pharmacy and Pharmacology September 1, 1963 DOI: 10.1111/j.2042-7158.1963.tb12802.x
Summary
AI-generated from the abstractTwo lysergic acid derivatives, BOL 148 and UML 491, counteracted the antidiuresis (reduced urine output) caused by 5-hydroxytryptamine (5-HT) in rats given a 1 mg/kg dose of 5-HT. BOL 148 at 5 mg/kg and UML 491 at 2.5 mg/kg each blocked this effect. However, neither compound blocked or reduced the antidiuretic effect of posterior pituitary extract. Neither BOL 148 nor UML 491 alone had any diuretic or antidiuretic action.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | BOL 148 UML 491 |
| Dose | BOL 148 5 mg/kg, UML 491 2.5 mg/kg, 5-HT 1 mg/kg |
| Key finding | BOL 148 and UML 491 counteract 5-HT-induced antidiuresis in rats but do not affect antidiuresis from posterior pituitary extract. |
Abstract
Abstract The effects of two lysergic acid derivatives, 2-bromlysergic acid diethylamide ‘BOL 148’ and 1-methyl-lysergic acid butanolamide ‘UML 491’ on the antidiuresis induced by 5-hydroxytryptamine ‘5-HT’ has been studied in rats given a dose of 1 mg./kg. 5-HT subcutaneously. BOL 148, 5 mg./kg., and UML 491, 2·5 mg./kg., counteracted the induced antidiuresis. By contrast, the antidiuretic effect of posterior pituitary extract was not blocked or diminished by BOL 148 or by UML 491. BOL 148 and UML 491 alone did not have a diuretic or antidiuretic action.