Blockade of 5-Hydroxytryptamine Antidiuresis in Rats by 2-Bromlysergic Acid Diethylamide Tartrate and 1-Methyl-Lysergic Acid Butanolamide
Journal of Pharmacy and Pharmacology September 1, 1963 A Chodera
Two lysergic acid derivatives, BOL 148 and UML 491, counteracted the antidiuresis (reduced urine output) caused by 5-hydroxytryptamine (5-HT) in rats given a 1 mg/kg dose of 5-HT. BOL 148 at 5 mg/kg and UML 491 at 2.5 mg/kg each blocked this effect. However, neither compound blocked or reduced the antidiuretic effect of posterior pituitary extract. Neither BOL 148 nor UML 491 alone had any diuretic or antidiuretic action.