Influence of cannabis use on incidence of psychosis in people at clinical high risk
Lucy Chester, L. Valmaggia, M. Kempton, E. Chesney, D. Oliver, Emily P. Hedges, Elise Klatsa, D. Ståhl, M. van der Gaag, L. de Haan, Barnaby Nelson, P. McGorry, G. Amminger, A. Riecher-Rössler, E. Studerus, R. Bressan, N. Barrantes-Vidal, Marie-Odile Krebs, B. Glenthøj, M. Nordentoft, S. Ruhrmann, G. Sachs, P. McGuire, Philip Mcguire, Maria Calem, S. Tognin, G. Modinos, E. Velthorst, T. Kraan, Daniëlla S. van Dam, Nadine Burger, C. Pantelis, Athena Politis, J. Goodall, S. Borgwardt, A. Gadelha, Elisa Brietzke, G. Asevedo, E. Asevedo, A. Zugman, Tecelli Domínguez-Martínez, Anna Racioppi, T. Kwapil, Manel Monsonet, L. Hinojosa, M. Kazès, C. Daban, J. Bourgin, O. Gay, C. Mam‐Lam‐Fook, M. Krebs, D. Nordholm, L. Randers, K. Krakauer, L. Glenthøj, Dominika Gebhard, Julia Arnhold, J. Klosterkötter, I. Lasser, B. Winklbaur, P. Delespaul, B. Rutten, J. van Os
Psychiatry and Clinical Neurosciences April 18, 2023 DOI: 10.1111/pcn.13555 via Semantic Scholar
Summary
AI-generated from the abstractCannabis use is associated with an increased risk of developing psychotic disorders among people already at clinical high risk for psychosis. In a prospective study of this population, cannabis use was linked to a higher incidence of psychotic disorders and to more persistent psychotic symptoms, as well as poorer functional outcomes. The findings strengthen evidence that cannabis acts as a risk factor for psychosis, though the direction of causality remains debated.
Study at a glance
| Characteristics | Prospective cohort study Peer reviewed |
|---|---|
| Population | People at clinical high risk of psychosis |
| Keywords | Medicine Psychology |
| Key finding | Cannabis use is associated with a higher incidence of psychotic disorders and more persistent psychotic symptoms in people at clinical high risk for psychosis. |
Abstract
Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome.