The effects of phencyclidine pretreatment on amphetamine-induced behavior and c-Fos expression in the rat.
Brain research January 12, 2001 DOI: 10.1016/s0006-8993(00)03056-0 via PubMed
Summary
AI-generated from the abstractA single injection of phencyclidine (PCP) enhances amphetamine-induced behaviors 24 hours later, resembling a schizophrenia-like state in animals, accompanied by altered c-Fos induction patterns. This study compared single versus subchronic PCP exposure on amphetamine-induced behaviors and c-Fos induction. No differences between the paradigms were observed; both enhanced amphetamine-induced c-Fos in the striatum, decreased c-Fos in the prefrontal cortex, and decreased cage-crossings. However, PCP pretreatment affected c-Fos induction similarly to previous studies while having an opposite effect on amphetamine-induced behavior, suggesting these effects are dissociated.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Animals (rats or mice implied) |
| Key finding | Single and subchronic PCP exposure similarly enhanced amphetamine-induced c-Fos in the striatum and decreased c-Fos in the prefrontal cortex and cage-crossings, but these neurochemical effects were dissociated from behavioral effects. |
Abstract
Previous data demonstrate that a single injection of phencyclidine enhances amphetamine-induced behaviors 24 h later, suggesting that the delayed effects of a single dose of phencyclidine may produce a schizophrenia-like state in animals. These behavioral changes were accompanied by altered patterns of c-Fos induction, suggesting possible neurochemical correlates to the observed behaviors. Because investigations into PCP's ability to model schizophrenia have found that the effects of repeated, or subchronic, PCP administration differ according to the dose and administration paradigm, this study sought to determine whether single and subchronic PCP exposure produce different effects on amphetamine-induced behaviors and c-Fos induction. No differences were observed between these administration paradigms; both single and subchronic PCP exposure enhanced amphetamine-induced c-Fos in the striatum, decreased c-Fos in the prefrontal cortex, and decreased the number of cage-crossings. However, the observation that PCP pretreatment affected c-Fos induction in the same manner observed previously while having an opposite effect on amphetamine-induced behavior suggests that these behavioral and neurochemical effects are dissociated.