The effects of phencyclidine pretreatment on amphetamine-induced behavior and c-Fos expression in the rat.
Brain research January 12, 2001 S M Turgeon, L C Case
A single injection of phencyclidine (PCP) enhances amphetamine-induced behaviors 24 hours later, resembling a schizophrenia-like state in animals, accompanied by altered c-Fos induction patterns. This study compared single versus subchronic PCP exposure on amphetamine-induced behaviors and c-Fos induction. No differences between the paradigms were observed; both enhanced amphetamine-induced c-Fos in the striatum, decreased c-Fos in the prefrontal cortex, and decreased cage-crossings. However, PCP pretreatment affected c-Fos induction similarly to previous studies while having an opposite effect on amphetamine-induced behavior, suggesting these effects are dissociated.