The PRISM Framework: Integrating Psychological, Regulatory, Behavioral, and Translational Domains in Psychedelic Clinical Trials
Open MIND January 1, 2026 DOI: 10.17605/osf.io/vd463 via OpenAlex
Summary
AI-generated from the abstractThe psychedelic clinical research field has grown rapidly, but its methods are often fragmented, focusing narrowly on pharmacology or subjective self-reports. The PRISM framework—Psychological Readiness, Regulatory & Ethical Safeguards, In-session Behavior Monitoring, Sense-making & Integration, and Meaningful Behavior Change—provides a translational approach that integrates behavioral science, ethical protocol design, and real-world functional outcomes to improve safety, data integrity, and therapeutic relevance in psychedelic trials.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Keywords | Clinical trial Prism Translational research Protocol science Relevance law |
| Key finding | The PRISM framework offers a translational approach integrating behavioral science, ethical protocol design, and real-world functional outcomes to enhance safety, data integrity, and therapeutic relevance in psychedelic trials. |
Abstract
The psychedelic clinical research field has seen rapid growth in recent years, yet methodological frameworks remain fragmented, often focusing narrowly on pharmacology or subjectove self-report outcomes. The PRISM framework- Psychological Readiness, Regulatory & Ethical Safeguards, In-session Behavior Monitoring, Sense-making & Integration, and Meaningful Behavior Change- offers a translational approach that integrates behavioral science, ethical protocol design, and real-world functional outcomes to enhance safety, data integrity, and therapeutic relevance in psychedelic trials.