Autophagy Enhancement with Spermidine and Rapamycin Microdosing

Spermidine triggers autophagy through pathways that do not involve mTOR, while a very low dose of rapamycin inhibits mTOR. Boosting autophagy may help clear built-up waste products and misshapen proteins in mevalonic aciduria, and it could also support cellular energy balance by improving the quality control of mitochondria.

Study at a glance

Abstract

Spermidine induces autophagy through mTOR-independent mechanisms while ultra-low dose rapamycin provides mTOR inhibition. Enhanced autophagy could clear accumulated metabolites and misfolded proteins in mevalonic aciduria while supporting cellular energy homeostasis through improved mitochondrial quality control.