The adverse events of ibogaine in humans: an updated systematic review of the literature (2015-2020).
Genís Ona, Juliana Mendes Rocha, José Carlos Bouso, Jaime E C Hallak, Tre Borràs, Maria Teresa Colomina, Rafael G Dos Santos
Psychopharmacology June 1, 2022 DOI: 10.1007/s00213-021-05964-y via PubMed
Summary
AI-generated from the abstractIbogaine, a hallucinogenic and psychostimulant alkaloid from the African shrub Tabernanthe iboga, is known for its anti-addictive properties, but its use is associated with serious adverse events and fatalities. A systematic review of 18 studies from 2015 to 2020 found highly heterogeneous results regarding the product used and dosages. Adverse events were classified as acute effects (within 24 hours) and persistent cardiac, psychiatric, and neurological alterations. The review highlights the need for phase I clinical trials to establish safety for standardized ibogaine products, and for research to identify vulnerable populations and develop effective screening and clinical procedures.
Study at a glance
| Characteristics | Systematic review Peer reviewed |
|---|---|
| Topics | Ibogaine |
| Keywords | Adverse events Drug interactions Ibogaine risks Noribogaine safety Careful use |
| Citations | 41 |
| Key finding | Adverse events associated with ibogaine/noribogaine administration include acute effects and persistent cardiac, psychiatric, and neurological alterations, but causation cannot be clearly established due to the predominance of case reports and non-controlled settings. |
Abstract
Ibogaine is the main alkaloid of the African shrub Tabernanthe iboga. It produces hallucinogenic and psychostimulant effects, but it is currently known for the anti-addictive properties. Despite the potential therapeutic effects, several cases of fatalities and serious adverse events related to ibogaine/noribogaine use can be found in the literature. Most studies consist in case reports or were conducted under non-controlled settings, so causation cannot be clearly established. To update (2015-2020) the literature on the adverse events and fatalities associated with ibogaine/noribogaine administration. Systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Eighteen studies were included in the final selection. Highly heterogeneous results were found in terms of kind of product used or the known dosages. The adverse events were classified in acute effects ( 24 h), mainly persistent cardiac alterations, psychiatric, and neurological signs. There is a high need of phase I clinical trials that can describe the safety of different dosages of ibogaine with standardized products. Further research should perform clinical profiling of vulnerable populations, and design effective screening methods and clinical procedures.