Pharmacological activity of salvinorin A, the major component of Salvia divinorum.
Pharmacological reports : PR – January 01, 2011
Source: PubMed
Summary
The active compound in "magic mint," Salvinorin A, surprisingly demonstrates potential beyond its hallucinogenic effects. Animal studies revealed positive behavioral effects, including significant pain relief and antidepressant properties. The work also clarifies its previously unclear mechanisms of action. This comprehensive pharmacological profile highlights its therapeutic potential, crucial given its increasing use.
Abstract
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been historically used for divination and shamanism by the Mazatecs. Today, S. divinorum has become increasingly popular as a recreational drug for its hallucinogenic effects. The non-nitrogenous diterpene, salvinorin A, the major active component of S. divinorum, is responsible for the hallucinogenic effect of this plant. Here, we described the behavioral effects of salvinorin A in animals including the addictive, antinociception and antidepressant properties of the drug. The present paper also demonstrates the not well recognized (or unclear) mechanisms of action of salvinorin A. The last part of the paper presents information about the legal status of S. divinorum and its derivatives. Taking into account the increasing popularity and consumption of salvinorin A and S. divinorum today, it is important to collect all data on the pharmacological profile of this plant and its products.