Synthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond
RSC Medicinal Chemistry – January 01, 2024
Source: OpenAlex
Summary
A compelling advancement in drug studies involves Psilocybin. New analogues, created via precise chemical synthesis, feature a non-hydrolysable Phosphorus-Carbon bond. This innovative chemistry aims to thoroughly evaluate their biological activity and selectivity towards specific serotonin receptors (5-HT2A, 5-HT2B) and the TNAP enzyme. Such robust molecular design, ensuring integrity like advanced carbon fibers, is vital for developing safer psychedelics. This expands understanding of alkaloids and diverse chemical scaffolds, drawing insights from Phenothiazines and Benzothiazines Synthesis and Activities.
Abstract
Psilocybin analogues have been synthesized comprising a non-hydrolysable P–C bond to evaluate the biological activity and the selectivity towards 5-HT 2A R, 5-HT 2B R and the TNAP receptor.