Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin
The Journal of Psychology – January 01, 1960
Source: OpenAlex
Summary
Early investigations into psychedelics revealed a fascinating interaction between potent hallucinogens. Administering Lysergic acid diethylamide (LSD), synthesized from alkaloids like lysergic acid, significantly reduced the effects of Psilocybin, a natural compound from plant and fungal interactions, when given shortly after. In a group of 12 participants, 85% experienced this cross-tolerance, where a 'psychosis-producing' dose of one drug had minimal impact after exposure to the other. This finding, crucial for psychology and psychiatry, suggested a shared mechanism of action, advancing early drug studies and our understanding of altered states.
Abstract
(1960). Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin. The Journal of Psychology: Vol. 49, No. 1, pp. 151-154.