Neurobiological Correlates of Psilocybin Response in Depression
The Primary Care Companion For CNS Disorders – May 22, 2023
Source: OpenAlex
Summary
A compelling discovery reveals psilocybin, a potent hallucinogen, may "reset" the brain. Functional neuroimaging, specifically functional magnetic resonance imaging, uncovers these transient brain changes. This "brain reset" phenomenon, observed after psilocybin therapy, could predict its antidepressant effectiveness in psychiatry. This insight from neuroscience and clinical psychology underscores the potential of psychedelics in medicine, suggesting avenues for rigorous randomized controlled trials.
Abstract
Conclusions: Transient functional brain changes with psilocybin therapy resemble the "brain reset" phenomenon and may serve as the putative predictors of psilocybin antidepressant response.