2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug
Science – November 03, 1967
Source: OpenAlex
Summary
The active compound in the hallucinogenic drug STP demonstrates remarkable potency. In human studies, doses exceeding 3 milligrams produced pronounced hallucinogenic effects lasting about 8 hours, akin to those from lysergic acid diethylamide and psilocybin. This substance, with its unique chemistry, is 100 times more potent as a hallucinogen than mescaline, yet only one-thirtieth as potent as lysergic acid diethylamide. Its pharmacology reveals a chemical relationship to amphetamine, like dextroamphetamine, offering mild euphoriant effects at lower doses. This work contributes to our understanding of psychedelics.
Abstract
We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic acid diethylamide, mescaline, and psilocybin. 2,5-Dimethoxy-4-methyl-amphetamine, which is chemically related to mescaline and amphetamine, is about 100 times more potent as a hallucinogen than mescaline and only one-thirtieth as potent as lysergic acid diethylamide. Its psychological effects are not accentuated by chlorpromazine.