Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice
Bioscience Biotechnology and Biochemistry – August 23, 2009
Source: OpenAlex
Summary
A novel hallucinogen, *Psilocybe argentipes*, significantly reduced obsessive-compulsive behaviors in an animal model, showing promise for psychology and drug studies. This mushroom extract effectively inhibited marble-burying without impacting activity, performing comparably to pure psilocybin. The pharmacology of this natural chemical synthesis suggests its alkaloids could influence neurotransmitter receptors, offering a new avenue for obsessive compulsive therapy. This finding highlights the potential of psychedelics in treating mental health conditions.
Abstract
Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.